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The Exclusion of Protein by Hyaluronic Acid

MEASUREMENT BY LIGHT SCATTERING

From the ¹ From the Department of Physical Biochemistry, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia

Light scattering measurements have been made on solutions of hyaluronic acid in the presence and absence of bovine serum albumin. The results are interpreted as showing an exclusion of bovine serum albumin from molecules of hyaluronic acid, the magnitude of which agrees with most other measurements of exclusion. The theory of the effect of heterogeneity of exclusion is given. The apparent heterogeneity that is observed is explained on statistical grounds. The results suggest that the main cause of exclusion is steric. No significant effect of bovine serum albumin on the configuration of the hyaluronic acid was observed.

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