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The Stereochemistry of the Nicotinamide Adenine Dinucleotide-specific Isocitric Dehydrogenase Reaction

From the ¹ From the Department of Biochemistry, The Institute for Cancer Research, Philadelphia, Pennsylvania 19111

The stereochemistry of the -ketoglutarate produced in the reaction of nicotinamide adenine dinucleotide-specific isocitric dehydrogenase with threo-d_s-isocitric acid-ß-T has been determined. The product retained the tritium of the substrate in the ß position without inversion. This is similar to the finding with the nicotinamide adenine dinucleotide phosphate-specific enzyme. The products of the two enzymes are therefore indistinguishable. Experiments with -ketoglutarate-ß-T₂ provided no evidence for the reversibility of the reaction.

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