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Evidence for the Chemical Interaction between 2-Mercaptoethanol and Tetrahydrofolate

From the ¹ From the Department of Experimental Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo 3, New York

Evidence is presented that tetrahydrofolate reacts chemically with 2-mercaptoethanol. The resulting product is more stable than tetrahydrofolate itself. The rate of decomposition of this derivative has been investigated. The possible sequences of interaction of tetrahydrofolate with 2-mercaptoethanol are discussed.

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