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Identification of a Functional Cysteine Essential for the Activity of Guinea Pig Liver Transglutaminase

From the ¹ From the National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

Inactivation of transglutaminase by ¹⁴C-iodoacetamide is accompanied by a proportional uptake of ¹⁴C-carbamidomethyl. Incorporation of 1 mole of this group per mole of enzyme results in complete inactivation. Proteolytic digestion of ¹⁴C-carbamidomethyl-labeled enzyme yields two related radioactive peptides containing the S-(¹⁴C-carbamidomethyl)cysteinyl residue. The amino acid sequences of these peptides have been determined as Gly-Gln-S-(carbamidomethyl)cysteine-Trp and Tyr-Gly-Gln-S-(carbamidomethyl)cysteine-Trp.

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