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Role of S-Adenosylmethionine in Vitamin B₁₂-dependent Methionine Synthesis

From the ¹ From the Laboratory of Clinical Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014

Methyl iodide can satisfy the requirement for S-adenosyl-methionine in transmethylation from N⁵-methyltetrahydro-folate to homocysteine catalyzed by a vitamin B₁₂ enzyme.

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				H. Weissbach The Isolation of the Vitamin B12 Coenzyme and the Role of the Vitamin in Methionine Synthesis J. Biol. Chem., August 29, 2008; 283(35): 23497 - 23504. [Full Text] [PDF]