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The Effect of Malate and Other Dicarboxylic Acids on Mitochondrial Isocitrate Metabolism

From the ¹ From the Department of Biochemistry, University of Toronto, Toronto 5, Canada

The increased isocitrate consumption of isolated rat liver mitochondria brought about by the addition of L-malate is quantitatively accounted for by increases in the production of both -ketoglutarate and citrate. The effect on citrate production is still observed under conditions such that the oxidation of isocitrate to -ketoglutarate is completely inhibited. The specificity of the effect has been investigated, and it is shown that a number of dicarboxylic acids can stimulate isocitrate metabolism in a similar fashion. Marked stereospecificity is indicated by the fact that among the tartrate stereoisomers only the meso form is active.

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