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Selective Stimulation of Ribonucleic Acid Synthesis in Prostatic Nuclei by Testosterone

From the ¹ From the Ben May Laboratory for Cancer Research and the Department of Biochemistry, University of Chicago, Chicago, Illinois 60637

Nearest neighbor frequencies and base composition of ribonucleic acid synthesized by the prostatic nuclei of castrated rats were altered by the injection of testosterone to the animals. Actinomycin D in vitro minimizes such differences. The results indicate that the androgen selectively enhances the synthesis of ribonucleic acids rich in guanine and cytosine.

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