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Deoxy-4-decarboxamido-oxytocin and Deamino-deoxy-4-decarboxamido-oxytocin

From the ¹ From the Department of Biochemistry, Cornell University Medical College, New York, New York 10021

Deoxy-4-decarboxamido-oxytocin and deamino-deoxy-4-decarboxamido-oxytocin have been synthesized and assayed for oxytocic and avian vasodepressor activities. Deoxy-4-decarboxamido-oxytocin was found to possess approximately 1.6 units per mg of oxytocic activity and approximately 3.5 units per mg of avian vasodepressor activity. Deamino-deoxy-4-decarboxamido-oxytocin is lacking in oxytocic activity and possesses a negligible amount of avian vasodepressor activity.

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