HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mudd, J. B. Search for Related Content PubMed PubMed Citation Articles by Mudd, J. B. Social Bookmarking                      What's this?

Reaction of Peroxyacetyl Nitrate with Glutathione

From the ¹ From the Department of Biochemistry and the Air Pollution Research Center, University of California, Riverside, California 92502

Peroxyacetyl nitrate reacts with the sulfhydryl groups of reduced glutathione. Thioester formation accounts for as much as 50% of the reacted sulfhydryl groups. As much as 60% of the reacted sulfhydryl groups can be accounted for as oxidized glutathione. The stoichiometry of the reaction is approximately 3 moles of sulfhydryl reacting per mole of peroxyacetyl nitrate, and this stoichiometry is the same over the pH range from 4.0 to 8.6 in acetate, phosphate, and tris-(hydroxymethyl)aminomethane buffers. Amino acid analyses of reduced and oxidized glutathione after treatment with peroxyacetyl nitrate show that cysteic acid is produced, but not in sufficient quantity to account for the decrease in cysine.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?