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Control of Exonuclease and Endolysin Synthesis during Development of Bacteriophage

From the ¹ From the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014

To obtain information on factors that control the expression of "early" and "late" phage functions during development, we have studied the formation of the two known -directed enzymes, exonuclease and endolysin, under various conditions of infection and lysogenic induction. The data indicate that exonuclease synthesis begins early in the latent period and is independent of phage DNA replication. In contrast, endolysin formation coincides with and appears to some extent to be dependent on DNA synthesis. During infection of the lysogen, K-12, by the virulent mutant, vir, exonuclease synthesis, but not that of endolysin, is partially repressed. From their relation to phage DNA replication, exonuclease and endolysin appear to be analogous to "early" and "late" enzymes, respectively, described during T-even phage infection. The results indicate that exonuclease and endolysin are encoded in different operons on the chromosome, of which only the "early" operon is under the direct control of the repressor.

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