Enzymatic Synthesis of Cytidine Diphosphate 3,6-Dideoxyhexoses
II. REVERSIBLE 2-EPIMERIZATION OF CYTIDINE DIPHOSPHATE PARATOSE
Sachiko Matsuhashi 1
From the
1 From the Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706
The reversible diphosphopyridine nucleotide-dependent 2-epimerization of cytidine diphosphate 3,6-dideoxy-d-glucose (CDP-paratose) and CDP-3,6-dideoxy-d-mannose (CDP-tyvelose) is described, both in a Group D Salmonella (Salmonella enteritidis) and in Pasteurella pseudotuberculosis, Type IV. Tyvelose is, thus, the only 3,6-dideoxyhexose which is synthesized from another member of this class of sugars. Some possible implications in the immunology of Salmonella are discussed.
Submitted on April 4, 1966