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From the
1 From the Department of Food Science and Technology, University of California, Davis, California
Ubiquinol-6 (reduced coenzyme Q6) was more effective than ubiquinone-6 and almost as effective as 
-tocopherol in reducing the stable free radical diphenyl-p-picrylhydrazyl.
The antioxidant activity of ubiquinol-6 was measured at low oxygen concentrations with an oxygen electrode. Ubiquinol-6 was found to be as efficient as -tocopherol as an inhibitor of the heme-catalyzed peroxidation of arachidonic acid emulsions.
Ubiquinol-6 was oxidized to ubiquinone-6 by free radical products of the heme-catalyzed decomposition of cumene hydroperoxide. -Tocopherol did not inhibit this reaction.
Light was used to catalyze the peroxidation of mitochondrial lipids at low concentrations of oxygen. This peroxidation was inhibited by the addition of ubiquinol-6 or -tocopherol to the mitochondria.
Light-induced mitochondrial peroxidation was inhibited by ubiquinol-6 produced from exogenous ubiquinone-6 by the electron transport-linked oxidation of ß-hydroxybutyrate.
Ubiquinols may function as antioxidants in the mitochondrion. This could explain why ubiquinones and related compounds have been found effective in the relief of certain vitamin E deficiency syndromes in some species.
Submitted on April 5, 1966
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