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Amino Acid Sequence of Whale Heart Cytochrome c

From the ¹ From the Department of Biological Chemistry, UCLA School of Medicine, University of California, Los Angeles, California 90024

The heart cytochrome c of the California gray whale, Rhachianectes glaucus, has been isolated. Peptides were isolated from a chymotryptic digest of the protein and the sequences were determined. By comparison with other mammalian cytochromes, the complete sequence could be assigned. Whale cytochrome c most closely resembles those from bovine, porcine, and ovine heart tissue, differing from these in only 2 residues. This finding is consistent with the view that the Cetacea were derived from mammals closely related to the Artiodactyla.

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