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The Chemical Degradation of Folic Acid

PHOTOLYSIS OF 2,4,7-TRIHYDROXYPTERIDINE

From the ¹ From the Department of Biochemistry, Tulane University School of Medicine, New Orleans, Louisiana 70112

2,4,7-Trihydroxypteridine is readily accessible from folic acid and other naturally occurring pteridines by way of 2-amino-4-hydroxypteridine-6-carboxylic acid, 2-amino-4-hydroxypteridine, and isoxanthopterin (2-amino-4,7-dihydroxypteridine). After irradiation with ultraviolet light and brief acid hydrolysis, 2,4,7-trihydroxypteridine gives rise to glyoxylic acid coming from carbon atoms 6 and 7 of the pteridine ring. A detailed method is described suitable for use on a micro scale in the study of the biosynthetic origin of these carbon atoms in pteridines.

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