HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Griffin, J. B. Articles by Hollocher, T. C. Search for Related Content PubMed PubMed Citation Articles by Griffin, J. B. Articles by Hollocher, T. C. Social Bookmarking                      What's this?

The Influence of pH on the Apparent Oxidation-Reduction Potential of Heart Muscle Succinic Dehydrogenase

From the ¹ From the Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02154

The electron spin resonance method has been used to study the effect of pH on the apparent oxidation-reduction potential of heart muscle succinic dehydrogenase over the pH range 6.5 to 8.5. This range lies beyond pK_a2 of the substrates, succinate and fumarate, but contains the range of pH where succinic dehydrogenase shows the highest activity in assay systems. The data suggest that dE'₀/dpH is 0 ± 3 mv x pH^-1.

We discuss this finding in connection with the mechanism of action of succinic dehydrogenase under conditions of exchange in the absence of supplementary oxidation-reduction constituents.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?