HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Billeter, M. A. Articles by Weissmann, C. Search for Related Content PubMed PubMed Citation Articles by Billeter, M. A. Articles by Weissmann, C. Social Bookmarking                      What's this?

Replication of Viral Ribonucleic Acid

X. TURNOVER OF VIRUS-SPECIFIC DOUBLE-STRANDED RIBONUCLEIC ACID DURING REPLICATION OF PHAGE MS2 IN ESCHERICHIA COLI

From the ¹ From the Department of Biochemistry, New York University School of Medicine, New York, New York 10016

Following infection of Escherichia coli with MS2, synthesis of parental type viral "plus" strands was preceded by the formation of complementary "minus" strands. Twenty-two minutes after infection, when the synthesis of progeny ribonucleic acid was well under way, the rate of synthesis of plus strands greatly exceeded that of minus strands. At this time there was a turnover of plus strands and little or no turnover of minus strands in MS2-specific double-stranded RNA. These results provide further support for the view that the replication of MS2 RNA proceeds in two steps. Minus strands are first synthesized with "plus" strands as template. The resulting replicative intermediate then acts as a template for the asymmetrical synthesis of progeny plus strands. In the latter process, newly formed plus strands displace their counterparts from the replicating complex.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				G. Feix, M. C. Schneider, C. Weissmann, and S. Ochoa Replication of Viral RNA: RNA Synthetase from Escherichia coli Infected with Phage MS2 or Qbeta Science, August 11, 1967; 157(3789): 701 - 703. [Abstract] [PDF]