JBC Transcription and Nuclear Factor Monoclonals

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The Effect of Actinomycin D on Post-phenobarbital Activity of Hepatic Microsomal Drug-metabolizing Enzymes in the Rat

John T. Wilson 1 and James R. Fouts 1

From the 1 From the Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, Iowa 52240

Administration of actinomycin D to rats, 24 hours after phenobarbital pretreatment, did not sustain or enhance the phenobarbital-induced increased activity of two hepatic microsomal drug-metabolizing enzymes. This was true whether the phenobarbital was given as a single dose or as multiple doses and at either of two doses of actinomycin D. No evidence for a repressor of hepatic microsomal drug-metabolizing enzymes was obtained in these studies.

Submitted on June 10, 1966


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