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Deoxyribosyl Transfer

III. CATALYSIS OF 3-PENTOSYLPURINE FORMATION BY PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES

From the ¹ From the Merck Sharp and Dohme Research Laboratories, Division of Merck and Company, Inc., Rahway, New Jersey 07065

The pyrimidine nucleoside phosphorylases, thymidine phosphorylase and uridine phosphorylase, catalyze the formation of 3-deoxyribosyl- and 3-ribosylpurines, respectively, from xanthine or some of its derivatives and the corresponding pentose phosphate. Although the rates of enzymatic cleavage of the deoxyribo- and ribonucleosides are approximately equal, the rate of synthesis of the deoxyribonucleoside is considerably greater than that of the ribonucleoside under comparable conditions.

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