Effect of Adrenal Steroids on a Na⁺- and K⁺-requiring Adenosine Triphosphatase from Rat Kidney

From the ¹ From the Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014

In the rat, kidney adenosine triphosphatase activity levels in the presence of sodium and potassium ((Na⁺ + K⁺)-ATPase) fall slowly after adrenalectomy, reaching a minimum on the 6th or 7th postoperative day. Kinetic data from kidney microsomal preparations indicate that this results from a decrease in enzyme levels rather than an alteration in the K_m values for ATP, sodium, or potassium.

The administration of aldosterone (10 µg) to adrenalectomized rats produced no detectable changes in kidney (Na⁺ + K⁺)-ATPase levels after 3 hours, even though maximal sodium retention may be observed at that time. However, corticosterone, when given in doses equivalent to the adrenal output, brought the kidney (Na⁺ + K⁺)-ATPase levels of adrenalectomized rats back to normal in 2 to 3 days.

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