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1ß-Hydroxylation of 3,17,20ß,21-Tetrahydroxy-5ß-pregnan-11-one and of Other 5ß-Steroids in a Man and by Surviving Liver Slices of the Guinea Pig

From the ¹ From the Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, and the Spectroscopy Applications Laboratories, Varian Associates, Palo Alto, California 94301

The 1ß-hydroxylation of 3,17,20ß,21-tetrahydroxy-5ß-pregnan-11-one was shown to occur in vivo in a man and in vitro by surviving liver slices of the guinea pig. The position and configuration of the metabolically introduced hydroxyl group were determined by chemical degradation and by nuclear magnetic resonance spectroscopy. This hydroxylation also was observed, but to a much smaller extent, when 3,17,21-trihydroxy-5ß-pregnane-11,20-dione and 5ß-pregnane-3,17,20-triol were administered to the same subject.

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