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Protein-synthetic Capacities of Liver Nuclear Subfractions

Kenneth S. McCarty 1, John T. Parsons 1, William A. Carter 1, and John Laszlo 1

From the 1 From the Departments of Biochemistry and Medicine, Duke University Medical Center, Durham, North Carolina 27706

The observations reported here indicate that rat liver nuclear subfractions possess the capacity to synthesize proteins by a mechanism resembling that found in the cytoplasm. The resistance of nuclear ribosomes to deoxyribonuclease, their magnesium optimum, and their sensitivity to puromycin and RNase, as well as their capacity to follow instructions dictated by either synthetic or endogenous messenger RNAs, are characteristics similar to those of cytoplasmic ribosomes. Sedimentation velocities and melting profiles of nuclear and cytoplasmic ribosomal RNA are identical.

In addition, similar base ratios of ribosomal RNA suggest the origin of nuclear and cytoplasmic ribosomes from the same genetic loci.

Submitted on May 9, 1966


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