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The Biosynthesis of Docosapentaenoic and Other Fatty Acids by Rat Testes

From the ¹ From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

The testicular biosynthesis of fatty acids was studied by intratesticular injection of ¹⁴C-labeled substrates and radioactivity determinations of the isolated individual fatty acids. After acetate-1-¹⁴C administration the highest specific activity was observed in palmitic acid, but stearic, oleic, arachidonic, and ^4,7,10,13,16-docosapentaenoic acids were also labeled. The former three were apparently formed predominantly by synthesis de novo. After ¹⁴C-linoleate injection the specific activities of polyenes peaked chronologically in the order eicosatrienoic, eicosatetraenoic, docosatetraenoic, and docosapentaenoic, suggesting that order for appearance of intermediates. Chemical degradation of docosapentaenoate synthesized after arachidonate-1-¹⁴C injection revealed essentially all the radioactivity in C-3, indicating direct elongation of arachidonate to docosapentaenoate by the testis.

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				K. D. Stark, S.-Y. Lim, and N. Salem Jr. Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid composition J. Lipid Res., November 1, 2007; 48(11): 2471 - 2477. [Abstract] [Full Text] [PDF]