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3agr-Ureido-11ß-hydroxy-Dgr4-androsten-17-one, a Novel Steroid Transformation in Man

Shunsaku Noguchi 1 and David K. Fukushima 1

From the 1 From the Institute for Steroid Research, Montefiore Hospital and Medical Center, New York, New York 10467

A highly polar human urinary metabolite, 3agr-ureido-11ß-hydroxy-Dgr4-androsten-17-one (ureasterone), has been isolated and characterized. This is the first known instance of combination of urea with a steroid in the metabolism of a hormone in man.

Submitted on September 24, 1965


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