JBC Focus on PI3-Kinase with Echelon

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Direct Release of Sugar from a Sugar Nucleotide

A NOVEL ENZYMATIC REACTION

Simonetta Sonnino 1, Hector Carminatti 1, and Enrico Cabib 1

From the 1 From the Instituto de Investigaciones Bioquímicas "Fundación Campomar" and Facultad de Ciencias Exactas y Naturales, Obligado 2490, Buenos Aires (28), Argentina

An enzyme which catalyzes the hydrolysis of guanosine diphosphate-glucose to guanosine diphosphate and glucose has been purified 130-fold from bakers' yeast extracts. Other sugar nucleotides as well as glucose 1-phosphate were not hydrolyzed.

Submitted on November 22, 1965


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