HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Joel, C. D. Search for Related Content PubMed PubMed Citation Articles by Joel, C. D. Social Bookmarking                      What's this?

Stimulation of Metabolism of Rat Brown Adipose Tissue by Addition of Lipolytic Hormones in Vitro

From the ¹ From the Department of Biological Chemistry, Harvard Medical School, and the Massachusetts Mental Health Center, Boston, Massachusetts 02115

1. The dose-response curves for the stimulation of the metabolism of slices of rat interscapular brown adipose tissue by addition of each of five lipolytic hormones in vitro are determined and compared with the corresponding curves determined with rat epididymal white adipose tissue under the same conditions.

2. Each of the five hormones studied is capable of stimulating both oxygen consumption and release of free fatty acids in brown adipose tissue. The dose-response curves for the action of norepinephrine, epinephrine, and glucagon on these two metabolic activities of brown adipose tissue are in concentration ranges which are very close to the corresponding curves determined with white adipose tissue. The dose-response curves for the action of adrenocorticotropic hormone and thyrotropin on brown adipose tissue are shifted to considerably higher concentrations than are the corresponding curves for white adipose tissue.

3. The ratio of oxygen consumption to free fatty acid release is several times higher in brown than in white adipose tissue, when the two tissues are compared while under maximal stimulation by any of the five hormones.

4. When brown adipose tissue is stimulated by catecholamines or glucagon, both the percentage of stimulation and the absolute rate of oxygen consumption are found to be unusually high for a mammalian tissue.

5. Further evidence is presented to support the hypothesis that the release of norepinephrine from sympathetic nerve endings within brown adipose tissue is a physiologically important means of activation of the high metabolic capabilities of this tissue.

6. Certain apparent advantages are enumerated which seem to make attractive the use of brown adipose tissue for further study of the primary chemical mechanisms of action of the five hormones investigated.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. Dicker, J. Zhao, B. Cannon, and J. Nedergaard Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1674 - R1682. [Abstract] [Full Text] [PDF]

				A. Angel Brown Adipose Cells: Spontancous Mobilization of Endogenously Synthesized Lipid Science, January 17, 1969; 163(3864): 288 - 290. [Abstract] [PDF]