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Biosynthesis of Mannophospholipids by Mycobacterium phlei

From the ¹ From the Department of Biochemistry, University of California, Berkeley, California 94720

The biosynthesis of the phosphatidylmyoinositol mannosides of Mycobacterium phlei has been shown to proceed from phosphatidylmyoinositol, probably with the sequential addition of single mannose residues.

An enzymatic system capable of incorporating the radioactivity of guanosine diphosphate mannose-¹⁴C into the phospholipid fraction was found in the 100,000 x g pellet of M. phlei cells which had been disrupted by sonic oscillation. Several properties of this system, including stimulation, specificity, and inhibition, have been studied. The radioactive product was found to be identical with 1-phosphatidyl-l-myoinositol 2-O--d-mannopyranoside, the structure of which was determined following its isolation as the intact ipid.

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