Parathyroid Hormone-induced Mitochondrial Swelling

From the ¹ From the Department of Biochemistry, Cancer Institute of Okayama University Medical School, Okayama, Japan, and the Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706

In addition to stimulating ion transport and respiration, it is now established that the parathyroid hormone induces rapid and extensive mitochondrial swelling. The swelling process takes place in the absence of Mg⁺⁺ in a medium composed of sucrose, substrate, and tris(hydroxymethyl)aminomethane. If Mg⁺⁺ is present, the swelling change is greatly minimized. The swelling is accompanied by a simultaneous increase in pyridine nucleotide oxidation and respiration, and is neither dependent upon nor enhanced by K⁺ or Na⁺. Inorganic phosphate, acetate, and, to a lesser extent, arsenate stimulate the rapidity and extent of the parathyroid hormone-induced swelling. The results suggest that parathyroid hormone-induced swelling is closely related to the ion transport and respiration responses.

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