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Reduction of Phenylpyruvic Acids to Phenyllactic Acids in Mammalian Tissues

From the ¹ From the Department of Pharmacology, New York University Medical School, New York, New York 10016

Evidence is presented that aromatic -keto acid reductase accounts for at least 80% of the total activity responsible for the reduction of aromatic -keto acids to their corresponding phenyllactic acids in mammalian tissues. The remaining activity can be attributed to lactic dehydrogenase, which is in keeping with the known broad substrate specificity of this enzyme. The relative contribution of aromatic -keto acid reductase and lactic dehydrogenase in a variety of mammalian tissues was determined with the use of sodium dodecyl sulfate, a potent inhibitor of lactic dehydrogenase.

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