JBC Avanti Polar Lipids

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On the Conversion of Cholesterol to 7agr,12agr-Dihydroxycholest-4-en-3-one

BILE ACIDS AND STEROIDS 168

Henry Danielsson 1 and Kurt Einarsson 1

From the 1 From the Department of Chemistry, Karolinska Institutet, Stockholm, Sweden

After incubation of cholesterol-4-14C, cholest-5-ene-3ß,7agr-diol-7ß-3H, and tritium-labeled 7agr-hydroxycholest-4-en-3-one with the 20,000 x g supernatant fluid of rat liver homogenate, 7agr,12agr-dihydroxycholest-4-en-3-one was identified as one of the main metabolites. In the presence of microsomal fraction fortified with reduced nicotinamide adenine dinucleotide phosphate, 7agr-hydroxycholest-4-en-3-one was converted into 7agr,12agr-dihydroxycholest-4-en-3-one as efficiently as in the 20,000 x g supernatant fluid. It is suggested that the main substrate for the 12agr-hydroxylase in cholic acid formation might be 7agr-hydroxycholest-4-en-3-one.

Submitted on September 2, 1965


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