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Amino Acid Transport in Bone

EVIDENCE FOR SEPARATE TRANSPORT SYSTEMS FOR NEUTRAL AMINO AND IMINO ACIDS

From the ¹ From the Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

1. A variety of naturally occurring and nonmetabolized amino acids were accumulated by fetal and adult calvaria in the rat by processes which are energy dependent, saturable, and sodium sensitive.

2. -Aminoisobutyric acid and glycine were transported by mediated processes which differ, at least in part, from those utilized for l-proline and hydroxy-l-proline. This conclusion is based on kinetic analysis and response to the removal of Na⁺ from the incubation medium.

3. -Aminoisobutyric acid and glycine were noted to be transported by mediated mechanisms in the absence of the Na⁺, suggesting the presence of two transport systems for these substrates in the osseous tissue used.

4. These results indicate that the dependence on Na⁺ may be a useful criterion with which to characterize transport mechanisms within the group of neutral amino acids, as well as between cationic and neutral substrates.

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