The Rate of Reaction of Carbon Monoxide with Hemoglobins M

From the ¹ From the Department of Biochemistry, Cornell University, Ithaca, New York 14850
² From the Veterans Administration West Side Hospital and Department of Medicine, University of Illinois, Chicago, Illinois 60612

The rate of reaction of the three abnormal hemoglobins, M_kankakee, M_chicago, and M_milwaukee, with carbon monoxide has been examined by flow and photochemical methods. In M_kankakee only one-half of the hemes become reduced and react with carbon monoxide. In the other two molecules, all of the hemes are reducible and react. M_kankakee and M_milwaukee are similar to one another and to hemoglobin A. M_chicago reacts faster and is kinetically heterogeneous. The result with M_kankakee implies that an adjacent chain containing ferric iron does not prevent the modification of ligand binding activity of the remaining chain which is usually described as heme-heme interaction.

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