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Purification of a Bovine Plasma Protein (Factor VII) Which Is Required for the Activity of Lung Microsomes in Blood Coagulation

From the ¹ From the Hematology Section of the Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

1. Factor VII, essentially free of Factor X but containing traces of prothrombin, and Factor X, very low in Factor VII, have been prepared by a combination of adsorption to and elution from barium sulfate and chromatography on diethylaminoethyl cellulose.

2. The activation of Factor X by lung microsomes is due to contamination of Factor X with Factor VII rather than to a direct attack on the Factor X molecule by lung microsomes.

3. Factor VII, lung microsomes, and calcium react to form a complex which is able to act as enzyme in activating Factor X. Indirect evidence has been obtained indicating the enzymatic activity of the complex is due to activated Factor VII.

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