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Effect of Hypophysectomy on Pyridine Nucleotide Metabolism

THE ROLE OF NICOTINAMIDE

From the ¹ From the Department of Biochemistry, Geigy Research, Division of Geigy Chemical Corporation, Ardsley, New York 10502

Hypophysectomy has been found to increase the half-life of injected nicotinamide. This increase in half-life has been shown to promote nicotinamide adenine dinucleotide synthesis for a longer period of time. These results, together with the increase in nicotinamide deamidase activity that occurs after hypophysectomy, are sufficient to explain the effect of hypophysectomy on the nicotinamide-induced elevation of NAD.

The increase in nicotinamide half-life in hypophysectomized animals results, at least in part, from a decreased rate of urinary excretion of the vitamin.

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