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Phosphoadenosine Diphosphate Ribose, a Specific Inhibitor of Nicotinamide Adenine Dinucleotide Phosphate Enzymes

From the ¹ From the Biochemistry Section, Weizmann Institute of Science, Rehovoth, Israel

Degradation products of nicotinamide adenine dinucleotide phosphate, formed under the hot mild alkaline conditions that are used in the determination of NADPH in the presence of NADP⁺, were found to inhibit the enzyme used for NADPH estimation.

The agent primarily responsible for inhibition was isolated and identified as phosphoadenosine diphosphate ribose.

Phosphoadenosine diphosphate ribose was found to be a very specific inhibitor for NADP⁺ dehydrogenases. It had no effect on NAD⁺-specific enzymes.

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