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A Soluble 2,3-Oxidosqualene Sterol Cyclase

From the ¹ From the Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138

An enzyme catalyzing the anaerobic cyclization of 2,3-oxidosqualene into lanosterol has been extracted from hog liver microsomes by treatment with deoxycholate. Removal of deoxycholate, delipidation with ether, and ammonium sulfate precipitation yield a soluble 20-fold purified cyclase. No coenzyme requirements could be demonstrated for the cyclization reaction.

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