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Metabolism of Thiols

S-GLUCOSYLATION

From the ¹ From the Department of Biochemical Pharmacology, School of Pharmacy, State University of New York at Buffalo, Buffalo, New York 14214

The metabolism of exogenous aromatic thiols (notably thiophenol and 5-mercaptouracil) was studied in four insect species (Gryllus assimilis, Blaberus giganteus, Blaberus craniifer, Anabrus simplex). Evidence was obtained for S-glucosylation in vivo and in vitro of thiophenol and 5-mercaptouracil. Authentic S-glucosyl-5-mercaptouracil was especially synthesized for the study. An incorporation study with fat body homogenate and UDP-¹⁴C-glucose revealed that S-glucosylation is an active biosynthetic pathway utilizing UDP-glucose rather than glucose as the closer precursor for the conjugation.

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