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Metabolism of Cholest-5-ene-3ß, 26-diol in the Rat and Hamster

From the ¹ From the Department of Medicine, New York University School of Medicine, New York, New York 10016

The Clemmensen reduction procedure has been adapted for the tritiation of kryptogenin to obtain cholest-5-ene-3ß, 26-diol-³H.

Intravenous administration of cholest-5-ene-3ß,26-diol to the bile fistula rat and hamster was followed by rapid excretion of bile acid metabolites in bile.

Cholic acid was identified as a metabolite of cholest-5-ene-3ß,26-diol by reverse isotope dilution in five hamsters and three rats.

In addition, a monohydroxy bile acid, 3ß-hydroxy-5-cholenoic acid, was identified as a metabolite of cholest-5-ene-3ß,26-diol. It seems possible, therefore, that a pathway from cholesterol to primary bile acid can exist which begins with the oxidation of the side chain to a C-24 carboxylic acid and is followed by alterations of the steroid ring.

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