HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shrago, E. Articles by Gordon, E. Search for Related Content PubMed PubMed Citation Articles by Shrago, E. Articles by Gordon, E. Social Bookmarking                      What's this?

Fatty Acid Synthesis in Human Adipose Tissue

From the ¹ From the Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706

The concentration of enzymes required for fatty acid synthesis was considerably less in extracts prepared from human omental adipose tissue than from rat epididymal fat. Overall rates of synthesis as measured by the incorporation of radioactive precursors into fatty acids were also much lower in human adipose tissue. The most striking difference was found with citrate-1,5-¹⁴C, human adipose tissue incorporating the compound at a rate less than one-tenth that of rat epididymal fat. This finding was consistent with the virtual absence of the citrate cleavage enzyme in human adipose tissue. By contrast, the activities of pyruvate carboxylase and phosphoenolpyruvate carboxykinase, two enzymes necessary for the synthesis of glyceride glycerol from pyruvate, and the long chain fatty acid activating enzyme (or enzymes) were essentially similar in both human and rat adipose tissues. The results are consistent with the hypothesis that synthesis de novo of fatty acids is not an important physiological function of human adipose tissue.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Amusquivar, F. J. Ruperez, C. Barbas, and E. Herrera Low Arachidonic Acid Rather than {alpha}-Tocopherol Is Responsible for the Delayed Postnatal Development in Offspring of Rats Fed Fish Oil Instead of Olive Oil during Pregnancy and Lactation J. Nutr., November 1, 2000; 130(11): 2855 - 2865. [Abstract] [Full Text] [PDF]

				S. Ranganathan and P. A. Kern Thiazolidinediones Inhibit Lipoprotein Lipase Activity in Adipocytes J. Biol. Chem., October 2, 1998; 273(40): 26117 - 26122. [Abstract] [Full Text] [PDF]

				P. A. Kern Potential Role of TNFalpha and Lipoprotein Lipase as Candidate Genes for Obesity J. Nutr., September 1, 1997; 127(9): 1917 - 1917. [Abstract] [Full Text]

				M. H. Hsu, S. S. Chirala, and S. J. Wakil Human Fatty-acid Synthase Gene. EVIDENCE FOR THE PRESENCE OF TWO PROMOTERS AND THEIR FUNCTIONAL INTERACTION J. Biol. Chem., June 7, 1996; 271(23): 13584 - 13592. [Abstract] [Full Text] [PDF]