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Physical Studies on the Light Density Ribonucleoprotein Complex of Macrophage Cells

From the ¹ From the Departments of Medicine, Harvard Medical School and the Robert Breck Brigham Hospital, Boston, Massachusetts 02120 and the Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138

A ribonucleoprotein complex of low molecular weight has been isolated from macrophage cells exposed in vitro to selected antigens. This ribonucleoprotein complex has the capacity to induce the formation of antibody directed against these antigens. The complex has a banding density of 1.588 g per cc in cesium sulfate solution and an s_20,w of 1.8. An approximate molecular weight of the complex, derived from its sedimentation coefficient, is 12,000. After removal of the protein component, the s_20,w falls to 1.3 S. The ribonucleoprotein complex has an R_f in 5% polyacrylamide gels of 0.35 and appears to be homogeneous with respect to molecular size in these systems.

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