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Studies on the Biosynthesis of Mannan in Micrococcus lysodeikticus

II. THE ENZYMATIC SYNTHESIS OF MANNOSYL-1-PHOSPHORYL-UNDECAPRENOL

From the ¹ From The Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
² From the Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

The carrier lipid involved in the enzymatic synthesis of mannosyl-1-phosphoryl-undecaprenol was isolated from the crude lipids of Micrococcus lysodeikticus and identified as undecaprenyl phosphate. In the presence of a particulate enzyme from M. lysodeikticus undecaprenyl phosphate serves as an acceptor of a mannosyl group from GDP-mannose, with concomitant production of GDP. Optimal rates of enzymatic synthesis of mannosyl-1-phosphoryl-undecaprenol require the presence of Mg⁺⁺ ion, and a surfaceactive compound, such as phosphatidylglycerol. An isomer of undecaprenyl phosphate, ficaprenyl (11) phosphate, serves as a substrate for mannosyl-1-phosphoryl-undecaprenol synthetase.

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