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Composition and Synthesis of Gangliosides in Rat Hepatocyte and Hepatoma Cell Lines

From the ¹ From the Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014, and Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

The composition of gangliosides and their synthesis in a chemically-induced rat hepatoma cell line differ from the composition and synthesis seen in a nontumorigenic rat hepatocyte cell line. The alteration in gangliosides is characterized by a decrease in disialoceramide tetrahexoside ganglioside and an increase in monosialoceramide lactoside (hematoside) and monosialoceramide tetrahexoside. The change resembles the altered pattern of gangliosides which occurs in mouse cell lines after transformation with oncogenic DNA viruses.

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				P. Fishman and R. Brady Biosynthesis and function of gangliosides Science, November 26, 1976; 194(4268): 906 - 915. [Abstract] [PDF]