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Differences between Slow and Fast Muscle Myosin

ADENOSINE TRIPHOSPHATASE ACTIVITY AND RELEASE OF ASSOCIATED PROTEINS BY p-CHLOROMERCURIPHENYLSULFONATE

From the ¹ From the Laboratory of Neurochemistry and Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014

The differences between slow and fast muscle myosin adenosine triphosphatase activity of the cat are described with reference to relative specific activities, p-chloromercuriphenylsulfonate activation, and alkaline and acid stability.

The treatment of fast muscle myosin with 8 moles of p-chloromercuriphenylsulfonate per 10⁵ g of myosin results in the release of two electrophoretically distinct proteins and loss of myosin ATPase activity.

There appears to be an inverse relationship between the degree of ATPase activity lost and the amount of closely associated proteins released from fast muscle myosin. Similar treatment of slow muscle myosin releases no proteins and causes no loss of ATPase activity.

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