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The Characterization and Occurrence of an S_f 20 Serum Lipoprotein

From the ¹ From the Department of Medicine and Biochemistry, College of Medicine, University of Florida, Gainesville, Florida 32601

In the serum of patients with hyper-pre-ß-lipoproteinemia there frequently occurs in abundance an ultracentrifugally distinct low density lipoprotein component of the S_f 20 class. This study concerns the characterization of this component, present in the serum of 14 of 15 patients. The lipoprotein has been isolated ultracentrifugally; it has the electrophoretic and immunological properties of a ß-lipoprotein but is distinct from very low density lipoproteins. It has a buoyant density of 1.004 g per ml which is lighter than the major low density lipoproteins of normal serum, and this observation is consistent with its higher triglyceride content. This lipoprotein has a sedimentation coefficient corrected for concentration and viscosity of -68 S, measured in a solvent of density 1.20 g per ml, and a molecular weight of approximately 4.2 million. Electron microscopy of this larger low density lipoprotein shows spherical macromolecules with a diameter approximating 256 A.

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