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Mechanism of Polypeptide Chain Termination

TRANSLATION OF TANDEM AMBER TERMINATION CODONS BY AN AMBER SUPPRESSOR TRANSFER RIBONUCLEIC ACID

From the ¹ From the Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
² From the Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

Unfractionated suppressor tRNA^tyr_SuSuiii⁺ can insert tyrosine at the nonsense site of an amber mutant of f2 bacteriophage but fails to synthesize polytyrosine in response to poly[r(U-A-G)]. Purified tRNA^tyr_SuSuiii⁺ can, however, propagate across a repeated U-A-G termination sequence and form polytyrosine as directed by poly[r(U-A-G)]. The recognition of tandem amber nonsense sequence only by the purified suppressor tRNA may be due to the increased concentration of tRNA^tyr_SuSuiii⁺.

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