HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnson, M. Articles by Ramwell, P. W. Search for Related Content PubMed PubMed Citation Articles by Johnson, M. Articles by Ramwell, P. W. Social Bookmarking                      What's this?

Carnitine-dependent ß Oxidation of Prostaglandins

From the ¹ From the Department of Physiology, Stanford University, Stanford, California 94305

The oxygen polarograph was used to follow prostaglandin oxidation by rat liver mitochondria. This system exhibits an absolute requirement for exogenous carnitine and ATP, in contrast to the oxidation of prostanoyl carnitine which is stimulated by ADP in a very similar manner to palmityl carnitine. Prostaglandin E₁, prostaglandin E₂, prostaglandin F₁, prostaglandin F₂, prostaglandin A₂, and 15-dehydroprostaglandin E₂ exhibited ADP:O ratios in the range of 1.3 to 2.0, which is typical of normal fatty acids. Our data thus indicate that prostaglandins utilize the common carnitine-dependent system for the ß oxidation of long chain fatty acids.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. Sjöquist, S. Basu, P. Byding, K. Bergh, and J. Stjernschantz The Pharmacokinetics of a New Antiglaucoma Drug, Latanoprost, in the Rabbit Drug Metab. Dispos., August 1, 1998; 26(8): 745 - 754. [Abstract] [Full Text]