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Primary Structure of Human Fibrinogen and Fibrin

I. CLEAVAGE OF FIBRINOGEN WITH CYANOGEN BROMIDE. ISOLATION AND CHARACTERIZATION OF NH₂-TERMINAL FRAGMENTS OF THE ("A") CHAIN

From the ¹ From the Department of Blood Coagulation Research, Karolinska Institutet, 104 01 Stockholm, Sweden

The cleavage of human fibrinogen in 70% formic acid with CNBr has been studied. A fragment containing the NH₂-terminal portions of the three chains has been obtained from the reaction mixture. After reduction and alkylation the NH₂-terminal fragments of the (A) and (AP) chains have been isolated in essentially pure form by gel filtration and chromatography. The amino acid sequence of these fragments has been determined. Evidence is presented for the occurrence in the (A) and (AP) chain preparations of the chain variants (AY) and (AYP).

The relation between structure and function of fibrinogen is discussed.

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