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From the
1 From the Molecular Disease Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014
The alanine apolipoprotein (apoLp-Ala) was isolated from patients with familial hyperlipoproteinemia (type V). ApoLp-Ala is a single chain protein of 79 amino acids with a single carbohydrate side chain containing 1 mole each of galactosamine and galactose, and 0 to 2 moles of sialic acid per mole of protein. The complete amino acid sequence of apoLp-Ala was determined by manual and automated Edman degradations of the intact protein, and tryptic and succinylated tryptic peptides. The NH2-terminal residue is serine, the COOH-terminal residue alanine. The carbohydrate moiety is attached to threonine at position 74 in the sequence. The amino acid sequence of apoLp-Ala contains no long sequences of hydrophobic residues which contrasts with the linear amphipathic regions present in the two integral membrane proteins cytochrome b5 and glycophorin.
The Complete Amino Acid Sequence of Alanine Apolipoprotein (apoC-III), an Apolipoprotein from Human Plasma Very Low Density Lipoproteins
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