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Glucocorticoid Receptors in Mouse Mammary Tumors

SPECIFIC BINDING OF GLUCOCORTICOIDS IN THE CYTOPLASM

From the ¹ From the Department of Zoology and Cancer Research Laboratory, University of California, Berkeley, California 94720

Specific binding of glucocorticoids was studied in the cytoplasmic extracts of mouse mammary tumors induced by mammary tumor virus. The binding protein satisfied all the general criteria of hormone receptors namely a specific high affinity for glucocorticoids (4 x 10^-9 m for dexamethasone) and limited number of binding sites which were saturated with low hormone concentrations (1 x 10^-8 m). It is suggested that the glucocorticoids may influence mammary tumor growth through the specific glucocorticoid receptors.

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