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JBC, Vol. 250, Issue 17, 6817-6821, Sep, 1975

The synthesis of 3-deoxyheptulosonic acid 7-phosphate

K. M. Herrmann and M. D. Poling

3-Deoxyheptulosonic acid 7-phosphate was obtained by a one-step chemical synthesis through condensation of oxalacetate with erythrose 4-phosphate. This reaction occurs at measurable rates only in the presence of a metal ion; Co2+ and Ni2+ are the most effective catalysts. The Co2+ catalyzed condensation of oxalacetate and erythrose 4-phosphate proceeds at room temperature and neutral pH. Since erythrose 4-phosphate can be replaced by any free aldehyde tested thus far, this type of a homogeneous catalysis opens new synthetic routes to alpha-keto-gamma-hydroxy-fatty acids and their derivatives.
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