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JBC, Vol. 250, Issue 23, 8889-8892, Dec, 1975

Function of 5'-nucleotidase in the uptake of adenosine from AMP by human lymphocytes

H. Fleit, M. Conklyn, R. D. Stebbins and R. Silber

The function of 5'-nucleotidase in nucleoside uptake from AMP was investigated in human lymphocytes by comparing the transport in cells containing this enzyme (5'N+) with that in cells deficient in the activity (5'N-). The rate of adenosine and Pi uptake from AMP was 3.9-fold greater in the 5'N+ then in the 5'N- lymphocytes. There was no difference in transport between these cells when incubated with adenosine or Pi. These results indicate that phosphorylytic cleavage of AMP by 5'-nucleotidase is necessary for the uptake of the nucleotide and Pi moieties by the human lymphocyte.
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